How to Choose Suitable Desiccators in the Pharmaceutical Industry

The drying device must comply with GMP requirements to ensure fairness in the drug production process, product uniformity, no accumulation, and can meet the requirements of online cleaning in Place (CIP). The drying device used for sterile raw materials must also meet the requirements of online sterilization in Place (SIP).
。 For various purposes, in the past two years, various raw material drug importing countries have put forward higher requirements for the production process and social responsibility of Chinese pharmaceutical enterprises. As a result, various certifications are rapidly being carried out in the pharmaceutical industry, and China's "Good Manufacturing Practice" (GMP) certification work is also accelerating. The focus of these certifications is on the refining, drying, and packaging positions for raw materials, and the fair selection of dryers is particularly important.
Vacuum rotary dryers originate from double cone mixers and are mostly cylindrical bodies with two conical ends, also commonly known as double cone dryers. The heating plate heats the drug to the specified temperature during the cyclic activity of the heating medium, and the water begins to evaporate and gradually withdraws with vacuum pumping.
China's accession to the WTO has brought both opportunities and new challenges to the pharmaceutical industry.
This device was developed by Shanghai Pharmaceutical Industry Research Institute in the 1980s and successfully tested in our company's penicillin production. It was quickly promoted in the national antibiotic industry, and there are currently many domestic manufacturers.
The equipment is easy to control and can condense and recover evaporated solvents. During the drying process, drugs are not easily contaminated and can be used for drug drying, packaging sterilization, and heat treatment. The drugs are dried while rolling in the dryer, ensuring the uniformity of the entire batch of drugs.
The vacuum drying oven is an ancient drying device, which is divided into several layers by a heating plate. There are two hollow suspension shafts in the middle of the cone, which are used for equipment rotation support and channels for vacuum and hot water. In the 1980s, the box type electric furnace was commonly used as the main dryer in the raw material pharmaceutical industry. However, due to the difficulty of online cleaning and sterilization of the material tray, the drying speed was slow, and the labor intensity of workers was high. In addition, in order to achieve drug uniformity, the box type electric furnace also needs to be mixed with powder after drying. Nowadays, it is rarely used in the production of raw material pharmaceuticals and is mostly used for small and medium-sized trial production or packaging material heat treatment of Shouli air compressor accessories. The hot medium enters the jacket through a hollow tube at one end, and the hot gas inside the device is discharged through the exhaust pipe in the hollow tube at the other end, and the volatile solvent is condensed and recovered.
Later, similar products such as single axis rotary dryers, multi-dimensional rotary dryers, and inclined rotary dryers emerged. Due to its simple operation and easy adjustment during intermittent production, as well as its ability to perform online cleaning and sterilization, this device has become the preferred dryer for small and medium-sized antibiotic raw material pharmaceutical enterprises, such as penicillin, lincomycin, chloramphenicol, caffeine, etc. Tubular furnace There are many types of API dryers in China, including vacuum drying oven, vacuum rotary dryer, three in one, airflow dryer, spray dryer, fluidized bed, fluidized bed, freeze dryer, etc. The following are brief descriptions of their respective characteristics and common premises.
The supporting equipment of this equipment includes vacuum system, solvent recovery system, cleaning and sterilization system, etc. Fill the heating plate with hot water or low-pressure steam as the heating medium, place the material tray to be dried on the heating plate, close the door of the tubular electric furnace, and use a vacuum pump to create a vacuum inside the box. When selecting equipment, the main consideration is the concentricity of the two hollow shafts and the sealing problem of the hollow shaft. To ensure smooth operation of the equipment, the concentricity requires a shaft end runout of less than 0.01mm. The sealing effect of the hollow shaft is mainly to prevent lubricant or filler from contaminating drugs.

The above content is organized by Superb heater Company, super heater. Mainly professional production: industrial heating elements, temperature measuring elements, production equipment, accessories, and raw materials such as tubular heaters, tubular heaters, belt heaters, ceramic heaters, silicone rubber heaters, thermocouples, etc.

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